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. 2013 Aug 6;173(3):502–511. doi: 10.1111/cei.12136

Figure 2.

Figure 2

(a) Immunohistochemical staining of lipocalin 2 (LCN2) in colonic biopsies from controls, active and inactive ulcerative colitis (UC), active and inactive Crohn's disease (CD). LCN2 is located in the infiltrating neutrophils and the epithelial cells, both with the appearance of enterocytes and goblet cells. We found significantly increased LCN2 expression in epithelium of active ulcerative colitis (UC) and active Crohn's disease (CD) versus controls. (b) In-situ hybridization of LCN2 in the same biopsies as immunohistochemical staining. The LCN2 mRNA is located only in the epithelial cells, indicating that these cells are responsible for de-novo synthesis. Also, we found significant expression of LCN2 mRNA in the epithelium of active disease versus healthy control mucosa. Original magnification ×10 and ×40.