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. 2013 Oct 15;170(5):968–977. doi: 10.1111/bph.12347

Figure 5.

Figure 5

Effects of exogenously applied primary afferent neuropeptides on submucosal venules. CGRP (10 nM) prevented the generation of spontaneous constriction with a dilation of venule (A). In the same venule that had been pretreated with CGRP8-37 (2 μM), CGRP-induced dilatation was largely attenuated. These results were summarized in (D). CGRP (10 nM)-evoked dilation of the venule was significantly attenuated by CGRP8-37 (n = 3, *P < 0.05). In a different venule, SP (100 nM) evoked a constriction of the venule (C). Resting diameters were 76 μm (A), 81 μm (B) and 71 μm (C). The scale bars in C apply to all traces.