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. 2014 Mar 11;9(3):e91223. doi: 10.1371/journal.pone.0091223

Table 1. Levels of cytokines in the lungs of mice subjected to the different sensitization and challenge protocols.

PBS OVA CRA HDM TAC
IL-4 [pg/ml] 3.12±1.04 57.43±12.54 (**,§§§) 55.20±8.51 (***,§§§) 64.15±6.99 (***,§§§) 239.1±26.54 (***)
IL-5 [pg/ml] 1.02±1.02 130.20±33.83 (**,§§) 74.57±10.57 (***,§§§) 81.15±11.5 (***,§§§) 345.50±61.15 (***)
IL-10 [pg/ml] 25.08±3.56 158.04±54.66 131.84±23.13 191.64±27.35 141.41±23.94
IL-13 [pg/ml] 3412±475.9 5198±699.5 4951±1451 6125±793.7 8310±1245 (***)
TGF-β1 [ng/ml] 134.4±25.55 125.3±16.23 140.9±14.33 229.6±65.15 (**) 205.2±46.52 (*)
IFN-γ [pg/ml] 2.41±0.52 0.65±0.3 (§§) 5.44±2.1 (§) 5.56±1.67(§) 21.06±6.06 (**)
IL-2 [pg/ml] 10.73±1.95 4.34±0.85 (§§) 4.54±1.0 (§§) 6.04±1.62 (§§) 44.51±14.12 (**)
IL-12 [pg/ml] 836.0±290.4 962.8±106.5 (§) 1284±125.7 1453±139.6 1649±167.0 (**)
IL-17 [pg/ml] 501.2±70.49 1458±110.9 (***) 1303±117.8 (***) 1038±82.58 (***) 858.7±78.4 (*)
IL-1ß [pg/ml] 544.17±154.49 1896.23±697.92 1590.43±347.75 1410.88±326.86 933.67±153.81

Values are expressed as mean ± SEM from 8–14 mice per group. *P <0.05, **P <0.01, ***P<0.001 in comparison to the PBS control and §< 0.05, §§< 0.01, and §§§<0.001 compared to the triple allergen combination (TAC) group.