Table 1. Levels of cytokines in the lungs of mice subjected to the different sensitization and challenge protocols.
PBS | OVA | CRA | HDM | TAC | |
IL-4 [pg/ml] | 3.12±1.04 | 57.43±12.54 (**,§§§) | 55.20±8.51 (***,§§§) | 64.15±6.99 (***,§§§) | 239.1±26.54 (***) |
IL-5 [pg/ml] | 1.02±1.02 | 130.20±33.83 (**,§§) | 74.57±10.57 (***,§§§) | 81.15±11.5 (***,§§§) | 345.50±61.15 (***) |
IL-10 [pg/ml] | 25.08±3.56 | 158.04±54.66 | 131.84±23.13 | 191.64±27.35 | 141.41±23.94 |
IL-13 [pg/ml] | 3412±475.9 | 5198±699.5 | 4951±1451 | 6125±793.7 | 8310±1245 (***) |
TGF-β1 [ng/ml] | 134.4±25.55 | 125.3±16.23 | 140.9±14.33 | 229.6±65.15 (**) | 205.2±46.52 (*) |
IFN-γ [pg/ml] | 2.41±0.52 | 0.65±0.3 (§§) | 5.44±2.1 (§) | 5.56±1.67(§) | 21.06±6.06 (**) |
IL-2 [pg/ml] | 10.73±1.95 | 4.34±0.85 (§§) | 4.54±1.0 (§§) | 6.04±1.62 (§§) | 44.51±14.12 (**) |
IL-12 [pg/ml] | 836.0±290.4 | 962.8±106.5 (§) | 1284±125.7 | 1453±139.6 | 1649±167.0 (**) |
IL-17 [pg/ml] | 501.2±70.49 | 1458±110.9 (***) | 1303±117.8 (***) | 1038±82.58 (***) | 858.7±78.4 (*) |
IL-1ß [pg/ml] | 544.17±154.49 | 1896.23±697.92 | 1590.43±347.75 | 1410.88±326.86 | 933.67±153.81 |
Values are expressed as mean ± SEM from 8–14 mice per group. *P <0.05, **P <0.01, ***P<0.001 in comparison to the PBS control and §< 0.05, §§< 0.01, and §§§<0.001 compared to the triple allergen combination (TAC) group.