Table 2. IL-4, IL-5, IL-10, TGF- β 1, IFN-γ, IL-2, IL-12, and IL-1β cytokine levels in the lungs of mice treated with dexamethasone, TLR7 or TLR9 agonists in the triple allergen challenge model (TAC).
| TAC | TAC/Dex | TAC/R848 | TAC/CpG | |
| IL-4 [pg/ml] | 402.7±48.14 | 369.4±77.26 | 390.4±70.62 | 84.42±16.76 (*) |
| IL-5 [pg/ml] | 687.7±210.3 | 409.9±79.52 | 540.4±81.16 | 177.9±54.19 (*) |
| IL-10 [pg/ml] | 221.0±119.9 | 226.8±141.4 | 428.2±125.0 | 2355±400.3 (***) |
| TGF-ß1 [ng/ml] | 196.8±45.26 | 430.2±171.2 | 370.3±89.30 | 198.8±45.40 |
| IFN-γ [pg/ml] | 71.71±21.47 | 51.56±13.37 | 116.1±11.04 | 210.9±65.80 (*) |
| IL-2 [pg/ml] | 122.7±37.34 | 90.68±36.76 | 228.7±26.38 | 184.1±41.75 |
| IL-12 [pg/ml] | 6.59±1.52 | 5.79±2.16 | 14.48±1.723 | 59.72±11.64 (***) |
| IL-1ß [pg/ml] | 3.21±0.77 | 2.67±0.52 | 3.43±0.37 | 10.37±2.23 (*) |
Treatment was started in the 4th week of allergen challenge with 1 mg/kg dexamethasone given orally, 1 mg/kg of R848, or 1 mg/kg CpG-ODNs, both given intratracheal. Values are expressed as mean ± SEM from 8–12 mice/group. *P <0.05, ***P<0.001 in comparison to the triple allergen combination (TAC) group.