Figure 5. The effect of gonadectomy and sex steroid replacement on dopamine, dopamine metabolites and dopamine turnover in the dorsal striatum of adolescent male rats.

There was no significant effect of treatment group on dopamine (A) or HVA (C). Gonadectomy increased DOPAC (B) and this increase was attenuated by testosterone replacement only. Dopamine turnover (D) was significantly increased by gonadectomy and this was attenuated by testosterone and DHT replacement but not 17β-estradiol replacement. * denotes comparison with Intact unless comparison indicated by a line, # denotes comparison with the Gdx group, * and # p<0.05; ** and ## p<0.01, n = 11–16/group for all.