Table 2. Summary of gene expression and protein changes in response to sex steroid replacement relative to the Gdx group.
Substantia nigra | Dorsal striatum | |||||
T | DHT | E | T | DHT | E | |
mRNA | ||||||
DAT | +++ | +++ | = | na | na | na |
VMAT | ++ | +++ | = | na | na | na |
DRD1 | = | ++ | = | = | = | = |
DRD2 pan | + | +++ | = | = | = | = |
DRD2S | ++ | ++ | = | = | = | = |
DRD2L | + | ++ | = | = | = | = |
DRD3 | - | - | = | = | = | = |
DRD4 | nd | nd | nd | nd | nd | nd |
DRD5 | ++ | + | + | = | = | = ? |
TH | = $ | = $ | = $ | na | na | na |
COMT | + $ | + $ | = $ | = | = | = |
MAOA | + $ | ++ $ | = $ | = | = | = |
MAOB | + $ | + $ | = $ | = | = | = |
protein | ||||||
DAT | +++ | = | = | = | = | = |
TH$ | +++ $ | = $ | = $ | = | = | = |
nd, not determined; na, not applicable; = , no change; +, <20% increase; ++, 20–30% increase; +++, >30% increase; -, <20% decrease; $, previously reported data [16].