Table 2. Summary of gene expression and protein changes in response to sex steroid replacement relative to the Gdx group.
| Substantia nigra | Dorsal striatum | |||||
| T | DHT | E | T | DHT | E | |
| mRNA | ||||||
| DAT | +++ | +++ | = | na | na | na |
| VMAT | ++ | +++ | = | na | na | na |
| DRD1 | = | ++ | = | = | = | = |
| DRD2 pan | + | +++ | = | = | = | = |
| DRD2S | ++ | ++ | = | = | = | = |
| DRD2L | + | ++ | = | = | = | = |
| DRD3 | - | - | = | = | = | = |
| DRD4 | nd | nd | nd | nd | nd | nd |
| DRD5 | ++ | + | + | = | = | = ? |
| TH | = $ | = $ | = $ | na | na | na |
| COMT | + $ | + $ | = $ | = | = | = |
| MAOA | + $ | ++ $ | = $ | = | = | = |
| MAOB | + $ | + $ | = $ | = | = | = |
| protein | ||||||
| DAT | +++ | = | = | = | = | = |
| TH$ | +++ $ | = $ | = $ | = | = | = |
nd, not determined; na, not applicable; = , no change; +, <20% increase; ++, 20–30% increase; +++, >30% increase; -, <20% decrease; $, previously reported data [16].