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. 2014 Mar 11;9(3):e91421. doi: 10.1371/journal.pone.0091421

Figure 4. Expression of IKK2ca impedes bone formation and reduces bone mineral density.

Figure 4

(A) Micro-CT analysis of four-week old Col2Cre+/IKK2ca heterozygote (Het) and WT littermate (n = 6/group). Col2Cre+/IKK2ca heterozygote has reduced trabecular bone in proximal tibia and femur compared to WT littermate. Quantitation of bone volume (BV) over total volume (TV), trabecular number (Tb.N), trabecular thickness (Tb.Th.) and trabecular separation (Tb.Sp.) is shown. (B) Bone formation rate - 4-week old mice (n = 6/group) were injected with two consecutive labels (arrows) of calcein (7 days apart) to measure bone formation rate. Asterisk represents p<0.05.