Table 4. Sensitivity of syphilis POC tests compared to clinical syphilis stage.

		Determine	Onsite	DPP (Trep)	Bioline
Clinical stage	N	Sens	Sens	Sens	Sens
		(95% CI)	(95% CI)	(95% CI)	(95% CI)
Primary	53*	100.0	88.7	84.9	77.3
		(91.6–100.0)	(76.3–95.3)	(71.9–92.8)	(63.5–87.3)
Secondary	70	100.0	98.6	94.3	94.3
		(93.5–100.0)	(91.2–99.9)	(85.3–98.2)	(85.3–98.2)
Early latent	91	95.6	93.4	92.3	86.8
		(88.5–98.6)	(85.7–97.3)	(84.3–96.6)	(77.7–92.7)
Late latent/unknown duration	25	96.0	88.0	84.0	84.0
		(77.7–99.8)	(67.7–96.8)	(63.1–94.7)	(63.1–94.7)
Past/treated	248**	93.1	89.9	88.3	84.7
		(89.1–95.8)	(85.3–93.2)	(83.5–91.9)	(79.4–88.8)

Clinical stage  =  documented in medical records for patient specimens; Sens = sensitivity; *Among Primary syphilis, 2 specimens were IA non-reactive but PCR positive. ** Among past/treated syphilis, 5 specimens were IA non-reactive.

Differences between estimates were considered to be statistically significant where 95% CI were not overlapping.