Figure 1. Animal weight changes following GR-agonist/antagonist treatment and CCI.

Influence of daily injections of the GR agonist dexamethasone (DEX), the GR antagonist RU-486 (RU), or vehicle (CON) in combination with chronic constriction injury (CCI) on the rat weight. Administration of the GR agonist resulted in a constant loss of weight, unaffected by CCI surgery. GR antagonist or vehicle treated animals exhibited a normal gain of weight, only slightly slowed down by the CCI surgery. Data are shown as mean ± s.e.m. **p<0.01, ***p<0.001 indicate significant differences between DEX and RU and ^#p<0.05, ^##p<0.01, ^###p<0.001 represent significant differences between DEX and CON.