Skip to main content
. 2014 Mar 11;9(3):e91692. doi: 10.1371/journal.pone.0091692

Figure 5. A summary of the interactions between T3 receptor subtype, and retinoic acid and glucocorticoid signaling in the T3-mediated control of gene expression described in this work.

Figure 5

T3 induces up regulation (+) or down regulation (−) of gene expression. Specificity of TR subtypes is depicted by a color gradient. Dio3 and Aldh1a1 require TRα1, but no clear preferences were detected for other genes. Transcriptionally direct T3 responses include Shh, Hr, and Klf9. Induction of Shh is probably involved in Dio3 regulation by T3. T3 regulates the expression of enzymes involved in the synthesis and degradation of retinoic acid (RA). The effect of T3 on Klf9 and on Aldh1a1 is potentiated by glucocorticoids, in part by up regulation of the glucocorticoid receptor Nr3c1.