Figure 5. Intestinal fatty acid absorption in control males (n = 5) and females (n = 6) and in intestine-specific CGI-58 knockout males (n = 6) and females (n = 6).

Mice at the age of 5 weeks were fed a HFD for 6 weeks, separated and individually housed, and then fed for 6 days a test diet including a fraction (5% of the total fat) of a non-absorbable marker sucrose poly-behenate (SPB). The fatty acid composition in both diet and feces, and the fractional absorption of total and individual fatty acids, were determined as described in Experimental Procedures. *P<0.05, **P<0.01 versus Control mice.