Table 1. Comparison of body weight, liver weight, and plasma parameters between control and intestine-specific CGI-58 knockout mice.
| Genotype and sex | ||||
| CGI-58f/f (Male) | CGI-58f/f/cre (Male) | CGI-58f/f (Female) | CGI-58f/f/cre (Female) | |
| BW (g) | 26.7±1.2 | 25.8±0.7 | 20.7±0.7 | 21.8±0.5 |
| Liver (g) | 1.5±0.1 | 1.4±0.1 | 1.3±0.2 | 1.4±0.1 |
| TG (mg/dl) | 37.15±3.27 | 36.50±2.13 | 32.66±3.63 | 25.19±2.46 |
| TC (mg/dl) | 126.5±10.7 | 168.3±9.7* | 92.7±2.6 | 102.8±3.3* |
| FC (mg/dl) | 28.30±2.16 | 37.67±2.12** | 20.46±0.55 | 22.92±0.93* |
| CE (mg/dl) | 164.0±14.7 | 218.1±13.5* | 120.6±3.8 | 133.4±4.3* |
| β-HB (mg/dl) | 7.50±0.18 | 7.95±0.51 | 8.90±0.35 | 9.66±0.43 |
| FFA (mmol/L) | 0.64±0.03 | 0.68±0.03 | 0.64±0.03 | 0.72±0.02 |
Eight to ten mice were fasted 4 h and weighed to record the body weight (BW). The mice were sacrificed for collection of tissue and blood samples. The entire liver of each mouse was weighed. Plasma parameters were measured as described under Experimental Procedures. Data were analyzed by two-tailed Student’s t test between CGI-58f/f (Control) and CGI-58f/f/cre mice within the same sex.
*P<0.05,
**P<0.01. TC, total cholesterol; FC, free cholesterol; CE, cholesterol ester that was calculated by multiplying the mass difference between TC and FC by 1.67; β-HB, β-hydroxybutyrate.