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A model of EGF-induced nuclear translocation of PKM2 and PKM2-promoted Warburg effect.
Upon EGF receptor activation, PKM2 is phosphorylated by ERK2 at S37. PIN1 binds to and isomerizes phosphorylated PKM2, resulting in the recruitment of importin 5 and translocation of PKM2 into the nucleus. Nuclear PKM2 binds to -catenin and enhances c-Myc expression, which subsequently increases the expression of GLUT1, LDHA, PTB and PKM2 itself, thereby promoting the Warburg effect and tumorigenesis.
