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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Neuropharmacology. 2013 Dec 4;79:249–261. doi: 10.1016/j.neuropharm.2013.11.022

Fig. 10.

Fig. 10

Telmisartan prevents the glutamate-induced alterations in Akt and GSK-3β phosphorylation in AT1A-deficient CGCs isolated from AT1A knock-out mice. The telmisartan effect is reduced by PPARγ inhibition. CGCs were pretreated with 1 µM telmisartan (Telm) followed by 1 hour exposure to glutamate (Glut) (100 µM). GW9662 (GW, 20 µM) was added 2 hours before telmisartan treatment. (A) Shown are representative Western blots for each protein level. Ratios of total and phospho-Akt (B) and phospho-GSK-3β (C) are presented as means ± SEM from three independent experiments. All results are shown as a percentage of the control group. **P < 0.01, ***P < 0.001 vs. control; ##P < 0.01 vs. Glut; $P < 0.05, $$$P < 0.001 vs. Glut+Telm.