Fig. 8.

Glutamate-induced neuronal injury is reduced in CGCs isolated from AT_1A receptor knock-out mice (KO) when compared with wild-type controls (WT). Primary CGCs from wild-type or AT_1A knock-out mice were exposed to different doses of glutamate (6.25 to 500 µM). The maximum glutamate-induced LDH release was significantly lower in CGCs obtained from AT_1A knock-out mice when compared to those from wild-type mice. Results are Means ± SEM for groups of three independent experiments. ***P < 0.001 vs. WT untreated controls ; ^#P < 0.05, ^###P < 0.001 vs. AT_1A KO untreated controls; ^$P < 0.05, ^$$$P < 0.001 WT vs. AT_1A KO.