Table 1.
Patient | Year of Transplant | Year of Diagnosis | Time from Transplant to Biopsy Diagnosis of BKVN (Months) | BKVN Stagea | Plasma BKV DNAb (copies/ml) | Biopsy Creatinine (mg/dL) | Post Biopsy Year 1 Creatinine (mg/dL) | Post Biopsy Year 2 Creatinine (mg/dL) | Post Biopsy Year 3 Creatinine (mg/dL) |
---|---|---|---|---|---|---|---|---|---|
1 | 1999 | 2000 | 20.2 | C | n/ac | 2 | n/a | n/a | 2 |
2 | 2000 | 2000 | 2.8 | A | n/a | 1.4 | 1.8 | 1.8 | 1.7 |
3 | 2001 | 2004 | 35.9 | C | 3.8 × 105 | 2.2 | 3.1 | HDd | |
4 | 2002 | 2003 | 11.5 | A | n/a | 2.6 | 3 | 2.8 | 2.8 |
5 | 2002 | 2005 | 33.6 | B | 1.3 × 106 | 2.2 | 2.7 | 3.5 | 4.1 |
6 | 2002 | 2004 | 22.2 | B | 2.0 × 105 | 1.2 | HD | ||
7 | 2003 | 2005 | 15.2 | B | 3.2 × 105 | 2 | 2 | 1.9 | 1.7 |
8 | 2005 | 2006 | 12.4 | B | 7.5 × 105 | 2 | 2 | 1.8 | 1.6 |
9 | 2005 | 2007 | 21 | A | 1.8 × 105 | 1.9 | 2.2 | 1.8 | 2 |
10 | 2005 | 2008 | 30.5 | A | 5.8 × 104 | 2.1 | 1.8 | 2.3 | 2.3 |
11 | 2005 | 2009 | 43 | A | 2.4 × 105 | 1.8 | 1.9 | 2 | 2.2 |
12 | 2005 | 2008 | 33.8 | C | 1.2 × 106 | 2.6 | 3.9 | HD | |
13 | 2006 | 2006 | 6.5 | A | 1.7 × 105 | 1.6 | 1.7 | 1.3 | 1.5 |
14 | 2006 | 2007 | 13 | A | 1.8 × 106 | 1.4 | 1.4 | 1 | 1 |
15 | 2006 | 2009 | 36.7 | B | 1.1 × 107 | 2.2 | 2.9 | 3.2 | 3 |
16 | 2006 | 2007 | 8.7 | A | 4.5 × 106 | 2.9 | 4 | HD | |
17 | 2006 | 2007 | 19.4 | B | 8.2 × 106 | 1.9 | HD | ||
18 | 2006 | 2007 | 12.5 | B | 5.6 × 106 | 3 | HD | ||
19 | 2006 | 2006 | 3.2 | B | 5.9 × 105 | 2.6 | HD | ||
20 | 2006 | 2006 | 6 | B | 1.6 × 104 | 6.1 | HD | ||
21 | 2007 | 2008 | 9.3 | B | 1.7 × 105 | 2.1 | 1.9 | 2 | 1.8 |
22 | 2008 | 2008 | 10.7 | B | 1.2 × 105 | 4.7 | 3.2 | 2.9 | 3.4 |
23 | 2008 | 2009 | 10.5 | A | 9.0 × 105 | 2.1 | 1.5 | 1.9 | 1.8 |
24 | 2008 | 2008 | 5.6 | A | 9.5 × 104 | 2.2 | 2.3 | 2.6 | 2.4 |
25 | 2008 | 2008 | 7.3 | A | 2.7 × 105 | 2.1 | 2.3 | 2.8 | 2.8 |
26 | 2008 | 2009 | 9.2 | B | 9.0 × 105 | 1.2 | 1.1 | 1.2 | 1 |
27 | 2008 | 2008 | 5.5 | A | 7.1 × 105 | 1.9 | 1.8 | 1.9 | 2.4 |
28 | 2008 | 2009 | 2.8 | B | 5.1 × 105 | 3.3 | 3.7 | HDc | |
29 | 2008 | 2009 | 12.2 | B | 2.5 × 105 | 3.5 | HD |
BKVN stage was determined using the Banff 2009 working proposal (14);
Plasma DNA copies were measured using commercially available assays (http://www.viracor.com)(24)
n/a=not available;
HD = return to hemodialysis.