Table 1. Annotation entry statistics for 341 human pulmonary hypertension-related genes.

Data category	Related entries	Annotated PH-related genes	Content/sources
General information
Human PH-related genes	341	341	Gene symbol, synonym, genomics position, gene type from Entrez gene database
Literature	365	341	Curated literature evidence for PH-related genes
Function and regulation
Pathway	3138	251	KEGG and HumanCyc database, etc.
Disease	5416	217	OMIM and GAD databases, etc.
Transcription factor regulation	5981	271	Regulatory reactions initiated by transcription factors from TRANSFAC
Post-translational modification	1451	199	Experimentally validated PTMs from dbPTM
Expression and methylation
Gene expression	765	282	Expression in PAH-related samples from GSE22356 and lung development related samples from GSE14334
Methylation	1197	250	Methylation profiles in promoter regions from the DiseaseMeth database
Genomic variation
Substitutions	8332	291	Single nucleotide mutations
Insertions/deletions	2151	36	Insertions and deletions
Other mutations	10 532	72	Others mutations
Functional interaction
Physical interactions	22 764	254	Physical protein–protein interactions from high throughput data
Metabolic interactions	446	72	Connected metabolic reactions
Signaling interactions	7349	150	Consecutive signaling transduction