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. 2014 Mar 1;28(5):423–431. doi: 10.1101/gad.236414.113

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© 2014 Stuwe et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 4. — Possible mechanisms of transgenerational effects of piRNAs. Maternally transmitted piRNAs can lead to stable piRNA production in the next generation by two mechanisms. In the nucleus, piRNAs in complex with PIWI could ensure piRNA precursor production by inducing establishment of a chromatin state over cognate piRNA clusters that permits piRNA production. Such a chromatin environment can either enhance transcription of the locus or result in channeling of the cluster transcript into the piRNA processing machinery or both. In the cytoplasm, the maternally deposited piRNAs associated with AUB could initiate cleavage of piRNA cluster transcripts in the Ping-Pong cycle.