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. 2014 Mar 1;28(5):451–462. doi: 10.1101/gad.236745.113

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© 2014 Roset et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 3. — ATM-dependent hematopoietic alterations in Rad50^+/46 mice. (A) Quantification of long-term hematopoietic stem cells (LT-HSC), short-term hematopoietic stem cells (ST-HSC), and MPPs in bone marrow from mice of the indicated genotypes. Bars denote the average ± standard error of mean (SEM). Rad50^+/+, n = 8; Rad50^+/46, n = 8,; Rad50^+/46 Atm^+/−, n = 2. (B) Quantification of CMP, granulocyte macrophage progenitor (GMP), megakaryocyte erythroid progenitor (MEP), and CLP. Bars denote the average ± SEM. Rad50^+/+, n = 5; Rad50^+/46, n = 5; Rad50^+/46 Atm^+/−, n = 2. P-values were determined by unpaired t-test. (C) Representative images and quantification of CFU-S assay at day 13 using bone marrow cells of the indicated genotype. Bars denote the average ± SEM of all the spleens obtained from three independent experiments. Rad50^+/+, n = 21; Rad50^+/46, n = 20; Rad50^+/46 Atm^+/−, n = 5. P-values were determined by unpaired t-test. (D) Kaplan-Meier survival curves of Atm^−/−, Rad50^S/S, Rad50^S/S Atm^−/− (previously published; Morales et al. 2005), Rad50^+/46, and Rad50^+/46 Atm^−/− mice. Rad50^+/46 mouse survival was not assessed beyond 18 mo, and thus the events were censored at that age.