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. 2014 Mar 1;28(5):451–462. doi: 10.1101/gad.236745.113

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© 2014 Roset et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 4. — Germ cell dysfunction in Rad50^+/46 mice. (A) Representative images of testis from mice of the indicated genotypes and average testes weight ± SEM (Rad50^+/+, n = 7; Rad50^+/46, n = 8; Rad50^+/46, Atm^+/− n = 5). Bar, 2.5 mm. (B) Representative images of anti-VASA-stained mid-ovary sections from 3-wk-old mice and quantification of the number follicles. Bar, 0.4 mm. Ovaries analyzed: n = 10. P-value was determined by unpaired t-test. (C) Hematoxylin and eosin (H&E), TUNEL, SYCP3, and PLZF immunohistochemical staining of testis sections from adult mice of the indicated genotypes. Bar, 50 μm. (D) Quantification of immunohistochemical staining from C. The TUNEL-positive area is expressed as a ratio to the total testis area. Testis analyzed: Rad50^+/+, n = 8; Rad50^+/46, n = 10; Rad50^+/46 Atm^+/−, n = 5. P-values were determined by unpaired t-test.