Table 2.
Assay results for the determination of IB and PA in their combined tablets.
| % of label claim (mean ± SD, n = 6) | ||||||
|---|---|---|---|---|---|---|
| Method | Alaxan | Dibulaxan | Febro | |||
| IB | PA | IB | PA | IB | PA | |
|
| ||||||
| HPLC | 99.4 ± 0.9 | 99.8 ± 0.9 | 99.8 ± 1.3 | 99.4 ± 1.0 | 100.3 ± 1.0 | 99.3 ± 1.2 |
|
| ||||||
| Derivative transform | ||||||
| 1D spectra | 99.5 ± 0.9 | 100.1 ± 1.4 | 100.3 ± 1.7 | 99.6 ± 1.3 | 99.4 ± 0.9 | 99.3 ± 1.3 |
| 1D ratio spectra | 99.8 ± 1.3 | 99.1 ± 1.1 | 100.2 ± 1.5 | 99.3 ± 0.9 | 99.4 ± 1.5 | 100.1 ± 1.4 |
|
| ||||||
| Wavelet transform | ||||||
| Sym6-spectra | 100.3 ± 1.8 | 99.6 ± 1.3 | 100.3 ± 1.5 | 99.4 ± 1.2 | 100.6 ± 0.8 | 99.1 ± 1.0 |
| Haar-spectra | 99.3 ± 1.3 | 99.1 ± 1.2 | 100.3 ± 0.9 | 99.7 ± 1.7 | 100.5 ± 1.2 | 99.4 ± 0.9 |
| Mexh-spectra | 101.0 ± 1.2 | 100.7 ± 0.8 | 100.5 ± 1.8 | 98.8 ± 1.3 | 99.4 ± 0.9 | 99.6 ± 1.1 |
| Sym6-ratio spectra | 100.1 ± 1.1 | 99.1 ± 1.3 | 99.4 ± 0.9 | 100.4 ± 0.9 | 99.2 ± 1.1 | 99.8 ± 0.9 |
| Haar-ratio spectra | 99.7 ± 0.9 | 99.3 ± 0.6 | 100.1 ± 1.0 | 99.6 ± 1.1 | 100.6 ± 1.3 | 99.5 ± 1.1 |
|
| ||||||
| Derivative-Wavelet transforms combined | ||||||
| Sym6-1D spectra | 100.8 ± 1.4 | 100.0 ± 1.0 | 99.7 ± 1.2 | 101.0 ± 1.1 | 99.5 ± 1.4 | 100.5 ± 0.9 |
| Haar-1D spectra | 99.5 ± 0.8 | 99.5 ± 1.0 | 100.7 ± 1.1 | 100.9 ± 1.3 | 100.7 ± 0.8 | 99.8 ± 0.8 |
| Mexh-1D spectra | 99.7 ± 1.0 | 99.5 ± 0.9 | 99.8 ± 1.3 | 100.2 ± 1.5 | 99.7 ± 0.9 | 99.8 ± 1.2 |
| 1D-Sym6 spectra | 100.5 ± 1.1 | 100.5 ± 0.8 | 99.8 ± 1.5 | 99.3 ± 1.4 | 100.6 ± 0.8 | 100.0 ± 1.1 |
| 1D-FWT spectra | 99.9 ± 1.4 | 100.4 ± 1.3 | 100.1 ± 1.3 | 99.9 ± 1.2 | 100.4 ± 1.1 | 100.4 ± 1.0 |
| Sym6-FWT spectra | 100.7 ± 1.1 | 100.3 ± 0.9 | 100.4 ± 1.1 | 99.7 ± 1.4 | 99.6 ± 0.9 | 100.1 ± 0.9 |
| Haar-FWT spectra | 99.8 ± 1.3 | 99.9 ± 1.0 | 99.7 ± 1.5 | 100.1 ± 1.0 | 100.4 ± 1.2 | 100.6 ± 1.0 |
| Mexh-FWT spectra | 100.3 ± 0.9 | 99.6 ± 1.4 | 99.5 ± 1.6 | 100.7 ± 0.8 | 100.6 ± 0.8 | 99.7 ± 1.3 |