Skip to main content
. Author manuscript; available in PMC: 2015 Feb 28.
Published in final edited form as: Neuroscience. 2013 Dec 17;260:106–119. doi: 10.1016/j.neuroscience.2013.12.023

Figure 2.

Figure 2

Nec-1 prevents BDNF delayed decrease in forebrain while increasing levels in diencephalon of male mice after HI along with greater TrkB receptor activation. Bar graphs showing BDNF levels (pg/mg of protein) stratified by sex in forebrain (A) and diencephalon (B) at 96h after HI. Representative blots showing a single band for pro-BDNF (34 kDa) and mature BDNF (14kDa) in forebrain and diencephalon are shown (C). BDNF receptors for forebrain and diencephalon are also shown: phospho-TrkB (pTrkB): TrkB ratio (145 kDa) (D, E); truncated TrkB (Tc.TrkB, 95kDa) (F, G); and p75ntr (64 kDa) (H, I). Bars represent the mean ± SEM measured in naive control (white), vehicle (light grey) and nec-1 (dark grey) treated male (solid color, M) and female (hashed color, F) mice. ‡, p ≤ 0.05, one-way ANOVA (M, male; F, female). p < 0.05 (Tukey’s post-hoc); *, vs. naive control; †, vs. vehicle; n= 4–8 mice/ treatment/ time/ sex.