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. Author manuscript; available in PMC: 2015 Mar 14.
Published in final edited form as: Neuroscience. 2014 Jan 3;262:165–175. doi: 10.1016/j.neuroscience.2013.12.043

Figure 3. TRPC4−/− rats resemble WT rats in plantar formalin and open field tests.

Figure 3

(A) Plantar Formalin Test

After hindpaw intraplantar injection of formalin, rats immediately showed typical formalin-induced nocifensive behaviors in a biphasic pattern, including: hindlimb favoring, lifting, biting/licking, and increased rearing and locomotion. The phase I begins immediately after the formalin injection and lasts about 10 min (2 blocks). Phase II typically begins 15 to 20 min after the formalin injection and continues for ≥45 min. There were no significant differences among the groups. (two-way ANOVA with Bonferroni post-test, P>0.05).

(B) Exploratory activity comparisons between wild type and TRPC4−/− animals During a 45 min-session of open field testing, both WT and TRPC4 −/− groups showed the same adaptive exploratory activity on the six parameters collected: rearing events, rearing duration, total beam broken, distance traveled; total active time and resting time. (T-test P>0.05)