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. Author manuscript; available in PMC: 2015 Mar 14.
Published in final edited form as: Neuroscience. 2014 Jan 3;262:165–175. doi: 10.1016/j.neuroscience.2013.12.043

Figure 4. TRPC4 is required for intracolonic mustard oil (MO) induced visceral pain-related responses and sensitized hindpaw plantar mechanical allodynia.

Figure 4

(A) Spontaneous pain behaviors. Bar graphs show increases in pain-related behaviors during a subsequent 25 min observation period after intracolonic infusion of mustard oil in male rats (n=7). Lower body licking and abdominal retractions were greatly increased in WT and TRPC4+/− rats. Responses were significantly less or did not appear in the TRPC4−/− rats, except some lower body licking. (TRPC4−/− vs. WT *p<0.05)

(B) Paw withdrawal threshold for mechanical stimulation. Paw withdrawal thresholds for mechanical stimulation with von Frey fibers were significantly reduced for WT and TRPC4+/− rats. TRPC4−/− rats maintained the same mechanical threshold 30 min after intracolonic mustard oil infusion (n=7). (***p<0.005 TRPC4+/− and TRPC4−/− vs. WT, ###p<0.001 TRPC4+/− vs. TRPC4−/−)