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. Author manuscript; available in PMC: 2015 Mar 14.
Published in final edited form as: Neuroscience. 2014 Jan 3;262:165–175. doi: 10.1016/j.neuroscience.2013.12.043

Figure 5. Visceral pain-related behaviors evoked by intracolonic mustard oil are blocked by oral pre-treatment with TRPC4 antagonist, ML-204.

Figure 5

(A) Spontaneous pain behavior. TRPC4 antagonist ML-204 administered orally inhibits MO-induced pain-related behaviors dose-dependently in wild type rats (n=4) (*p<0.05, **p<0.01, ***p>0.005 vs. vehicle).

(B) Mechanical hypersensitivity. ML-204 inhibits mechanical allodynia induced in WT rats by intracolonic MO infusion. The variation in baseline sample measurements was negligible. Values represent mean + SE of ~20 readings in rats (n=4, 1 hr after ML-204 administration).

(*p<0.05, **p<0.01 vs. vehicle)