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. Author manuscript; available in PMC: 2015 Mar 14.
Published in final edited form as: Neuroscience. 2014 Jan 3;262:165–175. doi: 10.1016/j.neuroscience.2013.12.043

Figure 6. Visceral pain-related behaviors evoked by intracolonic mustard oil are blocked by intraperitoneal application of TRPC4 antagonist, ML-204.

Figure 6

(A) Pre-treatment. TRPC4 antagonist ML-204, dose-dependently inhibited MO-induced pain-related behaviors in wild type rats injected intraperitoneally.

(B) Post-treatment. ML-204 inhibited pain-related behaviors induced by intracolonic MO infusion. Values represent mean ± SED (n=4, 1 hr).

(C) Pre-treatment. ML-204 inhibited mechanical allodynia induced in WT rats 30 minutes after intracolonic MO infusion.

(D) Responses to morphine. Inhibition of pain-related behaviors induced by intracolonic MO infusion after subcutaneous pre-treatment with morphine.

(*p<0.05, **p<0.01 vs. vehicle)

Abbreviations: PO vehicle–peanut oil; MO- mustard oil irritant