Table 1. Effect of ML-204 on Blood Pressure, Heart Rate and ECG Parameters.

ML-204 was gavaged with 1mg/kg in 10% sucrose 30min prior to taking ECG and blood pressure measurements. ML-204 administration had no effect on blood pressure, heart rate or ECG parameters.

		Mean Blood Pressure
		Baseline	30 min	1 hour
Control	n=2	111.0429	123.5556	127.7
ML-204	n=3	113.4222	120.9714	98.1553

ECG Parameters	HR (bpm)		CV (%) (LVP)		PQ (ms)		QRS (ms)		ST (ms)		QT (ms)
Animal Group n=	Before	After	Before	After	Before	After	Before	After	Before	After	Before	After
WT +ML204 n=3	449.89±16.8	424.89±2.65	1.289±0.14	0.86±0.21	28.92±1.54	29.6±0.28	15.4±0.92	15.41±0.56	53.73±3.65	57.59±1.1	68.11±4.56	72.02±1.68
TRPC4−/− +ML204 n=3	471.78±6.62	448.89±14.80	1.137±0.20	0.95±0.03	30.14±0.85	30.14±0.64	17.49±0.83	17.49±0.83	53.72±2.14	56.77±3.76	69.9±2.74	73.36±4.43