Figure 3.

Room-based place avoidance on a Stable and a Rotating arena. (A) Room-Stable place avoidance on a stationary dry arena with no demand for coordination of information from congruent spatial frames. Only a transient increase in the number of Entrances and a similar trend in the Shock Zone Occupancy were observed on day 1 on the Stable arena after either dose of MK-801. This effect was associated with transient hyperlocomotion after the high, but not the low dose of MK-801. (B) Room-Rotating Place Avoidance on a rotating dry arena with a high demand for coordination of information from the dissociated spatial frames. 0.15 mg/kg MK-801 persistently impaired all measures of avoidance and increased locomotion on the Rotating arena compared to the saline controls and 0.10 mg/kg MK-801. All rats improved their performance during training. *Significant effects of treatment; ^#significant effect of treatment × session interaction.