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Acute toxicity studies in mice and rats.
| Compound No | LD50(mg/kg) |
|
|---|---|---|
| Mice | Rats | |
| 4 | 1015 | 950 |
| 5 | 974 | 844 |
| 6 | 1300 | 1245 |
| 7 | 1136 | 1020 |
| 8 | 1035 | 985 |
| 9 | 1554 | 1470 |
| 10 | 1633 | 1580 |
| 11 | 1670 | 1513 |
| Ibuprofen (standard) | 750 | 650 |
LD50: dose that kills 50% of animals within 24 h after drug administration.
