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Factors associated with increased risk of bleeding with rivaroxaban [2]. *Care is to be taken in patients receiving concomitant systemic treatment with these agents and rivaroxaban. †Rivaroxaban is not recommended in patients receiving concomitant systemic treatment with these agents. ASA = acetylsalicylic acid; CrCl = creatinine clearance; CYP3A4 = cytochrome P450. 3A4; HIV = human immunodeficiency virus; NSAID = nonsteroidal anti-inflammatory drug; VKA = vitamin K antagonist.
