Table 1.

Change of prothrombin time in seconds (5–95% percentile) using various rivaroxaban doses and the STA Neoplastine CI Plus Assay [2].

Indication	Dose	PT at maximum plasma concentration (hours after ingestion)	PT at minimum plasma concentration (hours after ingestion)
Prevention of VTE	10 mg od	13–25 s (2–4 h)	Not studied
Treatment of VTE (first 3 weeks)	15 mg bid	17–32 s (2–4 h)	14–24 s (8–16 h)
Treatment of VTE (after 3 weeks)	20 mg od	15–30 s (2–4 h)	13–20 s (18–30 h)
Nonvalvular AF for stroke prevention	20 mg od	14–40 s (1–4 h)	12–26 s (16–36 h)
Nonvalvular AF for stroke prevention (CrCl <50 mL/min)	15 mg od	10–50 s (1–4 h)	12–26 s (16–36 h)

AF: atrial fibrillation; bid: twice daily; CrCl: creatinine clearance; od: once daily; PT: prothrombin time; VTE: venous thromboembolism.