Table 4. Stratification Analysis for HCC Associated Factors According to Genotypes a.
| Variables | Patients With Genotype B and I | Patients With Genotype C | ||
|---|---|---|---|---|
| P value | Hazard Ratio (95% CI) | P value | Hazard Ratio (95% CI) | |
| Univariate Analysis | ||||
| Sex | ||||
| Male | 0.00 | 17.85 (2.17 - 146.9) | 0.00 | 9.49 (3.76 - 23.91) |
| Female b | - | - | - | - |
| Ages, y | ||||
| < 30 b | 0.71 | - | 0.00 | - |
| 30 - 40 | 0.99 | 5E+008 (0.00-) | 0.00 | 23.14 (4.22 - 126.92) |
| 40 - 50 | 0.99 | 1E+009 (0.00-) | 0.00 | 60.00 (8.98 - 400.81) |
| 50 - 60 | 0.99 | 1E+009 (0.00-) | 0.00 | 75.00 (11.34 - 495.95) |
| ≥ 60 | 0.99 | 1E+009 (0.00-) | 0.00 | 18.00 (3.22 - 100.49) |
| BCP Wild-type b | ||||
| Mutations | 0.00 | 15.17 (3.95 - 58.32) | 0.00 | 60.42 (17.25 - 211.58) |
| DNA | ||||
| < 104 b | - | - | - | - |
| ≥ 104 | 0.10 | 2.73 (0.82 - 9.06) | 0.48 | 1.35 (0.59 - 3.09) |
| PreS deletions | ||||
| Wild-type b | - | - | - | - |
| Mutations | 0.99 | 5E+009 (0.00-) | 0.01 | 6.95 (1.54 - 31.34) |
| HBeAg | ||||
| Negative b | - | - | - | - |
| Positive | 0.16 | 3.90 (0.59 - 25.70) | 0.14 | 0.53 (0.22 - 1.24) |
| Anti-HBe | ||||
| Negative b | - | - | - | - |
| Positive | 0.81 | 1.15 (0.36 - 3.71) | 0.02 | 2.55 (1.15 - 5.65) |
| ALT | ||||
| Negative b | - | - | - | - |
| Positive | 0.03 | 4.58 (1.21 - 17.35) | 0.25 | 1.81 (0.66 - 5.00) |
| Multivariate Analysis | ||||
| Sex | 0.01 | 43.23 (2.70 - 692.1) | 0.00 | 19.31 (2.75 - 135.82) |
| BCP Mutations | 0.00 | 36.70 (3.84 - 350.7) | 0.00 | 241.62 (12.67 - 4609.3) |
| Ages, y | ||||
| < 30 b | - | - | 0.01 | 1 |
| 30 - 40 | 0.00 | 283.81 (8.07 - 9984.11) | ||
| 40 - 50 | 0.00 | 203.42 (8.84 - 4682.35) | ||
| 50 - 60 | 0.00 | 123.58 (5.80 - 2634.45) | ||
| ≥ 60 | 0.03 | 14.24 (1.33 - 152.58) | ||
a HBsAg asymptomatic carriers were the controls.
b The variable used for comparison.