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. 2014 Feb 17;14(2):e16214. doi: 10.5812/hepatmon.16214

Table 4. Stratification Analysis for HCC Associated Factors According to Genotypes a.

Variables Patients With Genotype B and I Patients With Genotype C
P value Hazard Ratio (95% CI) P value Hazard Ratio (95% CI)
Univariate Analysis
Sex
Male 0.00 17.85 (2.17 - 146.9) 0.00 9.49 (3.76 - 23.91)
Female b - - - -
Ages, y
< 30 b 0.71 - 0.00 -
30 - 40 0.99 5E+008 (0.00-) 0.00 23.14 (4.22 - 126.92)
40 - 50 0.99 1E+009 (0.00-) 0.00 60.00 (8.98 - 400.81)
50 - 60 0.99 1E+009 (0.00-) 0.00 75.00 (11.34 - 495.95)
≥ 60 0.99 1E+009 (0.00-) 0.00 18.00 (3.22 - 100.49)
BCP Wild-type b
Mutations 0.00 15.17 (3.95 - 58.32) 0.00 60.42 (17.25 - 211.58)
DNA
< 104 b - - - -
≥ 104 0.10 2.73 (0.82 - 9.06) 0.48 1.35 (0.59 - 3.09)
PreS deletions
Wild-type b - - - -
Mutations 0.99 5E+009 (0.00-) 0.01 6.95 (1.54 - 31.34)
HBeAg
Negative b - - - -
Positive 0.16 3.90 (0.59 - 25.70) 0.14 0.53 (0.22 - 1.24)
Anti-HBe
Negative b - - - -
Positive 0.81 1.15 (0.36 - 3.71) 0.02 2.55 (1.15 - 5.65)
ALT
Negative b - - - -
Positive 0.03 4.58 (1.21 - 17.35) 0.25 1.81 (0.66 - 5.00)
Multivariate Analysis
Sex 0.01 43.23 (2.70 - 692.1) 0.00 19.31 (2.75 - 135.82)
BCP Mutations 0.00 36.70 (3.84 - 350.7) 0.00 241.62 (12.67 - 4609.3)
Ages, y
< 30 b - - 0.01 1
30 - 40 0.00 283.81 (8.07 - 9984.11)
40 - 50 0.00 203.42 (8.84 - 4682.35)
50 - 60 0.00 123.58 (5.80 - 2634.45)
≥ 60 0.03 14.24 (1.33 - 152.58)

a HBsAg asymptomatic carriers were the controls.

b The variable used for comparison.