Table 3.
Genotype and allele frequencies distribution in different sepsis status and healthy controls.
| Genotype | Healthy control N (%) | Sepsis (subtype) N (%) | Septic shock N (%) | Severe sepsis N (%) | P value | P value* | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| P 1 | P 2 | P 3 | P 1* | P 2* | P 3* | |||||
| rs2910164 | ||||||||||
| Total | 206 | 34 | 65 | 127 | 0.712 | 0.888 | 0.0045 | 0.712 | 0.888 | 0.0045 |
| CC | 101 (49.03) | 15 (44.12) | 31 (47.69) | 42 (33.07) | ||||||
| GG/GC | 105 (50.97) | 19 (55.88) | 34 (52.31) | 85 (66.93) | ||||||
| Allele | ||||||||||
| C | 295 (71.60) | 46 (67.65) | 91 (70.00) | 153 (60.24) | ||||||
| G | 117 (28.40) | 22 (32.35) | 39 (30.00) | 101 (39.76) | 0.564 | 0.740 | 0.0029 | 0.712 | 0.888 | 0.0045 |
|
| ||||||||||
| rs57095329 | ||||||||||
| Total | 205 | 33 | 62 | 127 | 0.560 | 0.278 | 0.413 | 0.613 | 0.503 | 0.421 |
| AA | 135 (65.85) | 20 (60.61) | 46 (74.19) | 78 (61.42) | ||||||
| GG/GA | 70 (34.15) | 13 (39.39) | 16 (25.81) | 49 (38.58) | ||||||
| Allele | ||||||||||
| A | 334 (81.46) | 52 (78.79) | 105 (84.68) | 200 (78.74) | ||||||
| G | 76 (18.54) | 14 (21.21) | 19 (15.32) | 54 (21.26) | 0.613 | 0.503 | 0.421 | 0.613 | 0.503 | 0.421 |
OR: odds ratio; 95% CI: 95% confidence interval. *False discovery rate-adjusted P value for multiple hypotheses testing using the Benjamini-Hochberg method. P 1 and P 1*: healthy control group versus sepsis group. P 2 and P 2*: healthy control group versus septic shock group. P 3 and P 3*: healthy control group versus severe sepsis group. Fisher's exact test P 3 = 0.0045, OR = 1.947, 95% CI (1.229–3.083) for genotype in rs2910164; P 3 = 0.0029, OR = 1.664, 95% CI (1.196–2.316) for allele in rs2910164.