Table 1.
LTB4 (ng/mL) in plasma, synovial fluid (SF), soluble (SO), and solubilized membrane-bound (MB) fractions from synovial tissue (ST) and peripheral blood mononuclear cells (PBMCs) from control, CIA-arthritic, and CIA-resistant rats.
| Samples | Control | CIA-arthritic | CIA-resistant | ANOVA |
|---|---|---|---|---|
| PLASMA | 0.1454 ± 0.0006a | 0.2119 ± 0.0208b | 0.2130 ± 0.0125ab | P = 0.0223 |
| SF | 0.0283 ± 0.0037a | 0.0552 ± 0.0061b | 0.0538 ± 0.0086b | P = 0.0214 |
| SO-ST | 0.4038 ± 0.0072a | 0.1452 ± 0.0262b | 0.1836 ± 0.0560b | P = 0.0090 |
| MB-ST | 0.0954 ± 0.0006a | 0.1581 ± 0.0039b | 0.1194 ± 0.0006c | P = 0.0007 |
| SO-PBMCs | 0.7163 ± 0.0141a | 0.6975 ± 0.0168a | 0.4368 ± 0.0139b | P < 0.0001 |
| MB-PBMCs | 0.3045 ± 0.0636a | 0.0555 ± 0.0050b | 0.0684 ± 0.0021b | P = 0.0051 |
Values are mean ± SEM. Number of animals = 3, values of each animal measured in duplicate. Student-Newman-Keuls, P < 0.05: comparison among control versus CIA-arthritic versus CIA-resistant in the same row (different letters indicate significant difference).