Table 5.
Comparison of simulation parameter constraints and experimental data
| Constraint | ON RGCs | Model Constraints | Experimental data |
|---|---|---|---|
| C0 | Spikes overshoot 0 mV | ||
| C1 ON | resting potential | [−62, −70] mV | −65.5± 1.3 mV |
| C2 ON | Spontaneous Frequency | 0 Hz | 0 Hz |
| C3 ON | Spike rate during 500 ms stimulus of −0.2 nA | 0 Hz | 0 Hz |
| C4 ON | Burst rate at the termination of 500 ms stimulus of −0.2 nA | 0 Hz | 0 Hz |
| OFF RGCs | Model Constraints | Experimental data | |
| C0 | Spikes overshoot 0 mV | ||
| C1 OFF | resting potential | [−50, −62] mV | −54.6 ± 1.0 mV (OFF T) −55.1± 1.1 mV (OFF S) |
| C2 OFF | Spontaneous Frequency | [15, 23] Hz (OFF T) | 20.3 ± 3.0 Hz (OFF T) |
| [40, 48] Hz (OFF S) | 43.3 ± 3.5 Hz (OFF S) | ||
| C3 OFF | Spike rate during 500 ms stimulus of −0.2 nA | 0 Hz | 0 Hz |
| C4 OFF | Burst rate at the termination of 500 ms stimulus of −0.2 nA | Rebound excitation ≥ 2 × spontaneous frequency | Rebound excitation 60 Hz |