Fig. 1.

a The conservation of the PIR promoter sequence in the genomes of the chimpanzee, rhesus monkey, mouse, rat, and cow in relation to the human. The following features are marked: the TSS; the most conserved region containing putative ARE (asterisk); the predicted CpG island (white bar); the promoter fragments used in the luciferase constructs (black bars). b The enlargement of the alignment of DNA region marked on (a) with asterisk. The putative ARE, located between positions +281/+291 in the human gene, is shown