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. 2014 Mar 12;4:4361. doi: 10.1038/srep04361

Figure 7. Vitamin C enhances iSC reprogramming (Protocol 4).

Figure 7

(A) Experimental timeline. Radiation-inactivated murine embryonic fibroblasts were plated at one day before (D-1) human dermal fibroblasts (HDF) were plated (day zero, D0). Cultures were treated as described in Figure 6, except the cultures were treated with proteins for 6 hours each day in HDF media containing 0, 1 or 10 mg/ml L-ascorbic acid. (B) Vitamin C enhances iSC colony formation. The percent of treated cells that gave rise to iSCs is tabulated based on the means of three separate experiments ± s.d. (n = 3/group). * p < 0.001 as determined by a Student's unpaired t-test.