Table 2.
Results of preparation of fluorescein-loaded polymeric micelles.
| Code | Fluorescein in feed [wt%] | Yield mg (%) |
PR [%] | DL [%] | EE [%] | DR [%] |
|---|---|---|---|---|---|---|
| b-PLLA(0) | 0 | 21.0 (84) | 84 | 0.0 | — | — |
| b-PLLA(10) | 10 | 16.7 (60) | 60 | 10.4 | 104 | 63 |
| b-PLLA(15) | 15 | 16.0 (54) | 55 | 13.5 | 90 | 49 |
| b-PLLA(20) | 20 | 14.4 (46) | 48 | 16.9 | 85 | 39 |
| b-PLLA(25) | 25 | 12.1 (36) | 40 | 17.9 | 72 | 26 |
| b-PLLA(30) | 30 | 7.0 (20) | 23 | 16.6 | 60 | 11 |
| b-PLLA(35) | 35 | 1.6 (4) | 5 | 14.5 | 41 | 1.7 |
|
| ||||||
| b-PDLLA(0) | 0 | 22.3 (89) | 89 | 0.0 | — | — |
| b-PDLLA(10) | 10 | 22.3 (80) | 79 | 11.6 | 116 | 93 |
| b-PDLLA(15) | 15 | 20.0 (68) | 69 | 13.9 | 92 | 63 |
| b-PDLLA(20) | 20 | 21.2 (68) | 71 | 16.3 | 82 | 55 |
| b-PDLLA(25) | 25 | 16.9 (51) | 56 | 17.8 | 71 | 36 |
| b-PDLLA(30) | 30 | 13.8 (39) | 44 | 20.0 | 67 | 26 |
| b-PDLLA(35) | 35 | 2.7 (7) | 9 | 19.9 | 57 | 4.0 |
|
| ||||||
| b-PLGL 20 (0) | 0 | 22.0 (89) | 89 | 0.0 | — | — |
| b-PLGL 20 (25) | 25 | 24.9 (75) | 78 | 21.7 | 87 | 65 |
| b-PLGL 20 (30) | 30 | 23.1 (65) | 72 | 21.7 | 72 | 47 |
| b-PLGL 20 (35) | 35 | 12.9 (34) | 41 | 20.2 | 58 | 19 |
| b-PLGL 20 (40) | 40 | 5.2 (12) | 16 | 22.0 | 55 | 6.9 |
|
| ||||||
| b-PLGL 37 (0) | 0 | 20.4 (82) | 82 | 0.0 | — | — |
| b-PLGL 37 (25) | 25 | 26.8 (80) | 83 | 22.4 | 90 | 72 |
| b-PLGL 37 (30) | 30 | 29.7 (83) | 86 | 27.8 | 93 | 77 |
| b-PLGL 37 (35) | 35 | 18.9 (49) | 56 | 25.3 | 72 | 36 |
| b-PLGL 37 (40) | 40 | 6.6 (16) | 20 | 25.6 | 64 | 10 |
|
| ||||||
| b-PLGL 49 (0) | 0 | 20.7 (83) | 83 | 0.0 | — | — |
| b-PLGL 49 (25) | 25 | 27.6 (83) | 82 | 25.5 | 102 | 85 |
| b-PLGL 49 (30) | 30 | 25.8 (72) | 73 | 29.0 | 97 | 70 |
| b-PLGL 49 (35) | 35 | 19.5 (51) | 55 | 29.2 | 83 | 42 |
| b-PLGL 49 (40) | 40 | 9.0 (22) | 27 | 24.1 | 60 | 13 |
|
| ||||||
| b-PLGL 59 (0) | 0 | 22.6 (90) | 90 | 0.0 | — | — |
| b-PLGL 59 (25) | 25 | 26.5 (80) | 81 | 24.0 | 96 | 76 |
| b-PLGL 59 (30) | 30 | 28.1 (79) | 81 | 27.7 | 92 | 73 |
| b-PLGL 59 (35) | 35 | 19.8 (51) | 56 | 29.0 | 83 | 43 |
| b-PLGL 59 (40) | 40 | 7.1 (17) | 20 | 29.6 | 74 | 12.6 |
|
| ||||||
| b-PLGL 75 (0) | 0 | 22.8 (91) | 91 | 0.0 | — | — |
| b-PLGL 75 (25) | 25 | 26.9 (81) | 81 | 24.8 | 99 | 80 |
| b-PLGL 75 (30) | 30 | 25.7 (72) | 72 | 29.6 | 99 | 71 |
| b-PLGL 75 (35) | 35 | 19.2 (50) | 55 | 28.9 | 83 | 41 |
| b-PLGL 75 (40) | 40 | 11.1 (27) | 32 | 28.5 | 71 | 19 |
|
| ||||||
| b-PLGF 24 (0) | 0 | 23.0 (92) | 92 | 0.0 | — | — |
| b-PLGF 24 (24) | 25 | 22.9 (69) | 73 | 20.6 | 82 | 57 |
| b-PLGF 24 (30) | 30 | 22.3 (62) | 68 | 23.7 | 79 | 49 |
| b-PLGF 24 (35) | 35 | 12.7 (33) | 39 | 24.1 | 68 | 23 |
| b-PLGF 24 (40) | 40 | 8.8 (21) | 27 | 22.0 | 55 | 12 |
|
| ||||||
| b-PLGF 49 (0) | 0 | 20.8 (83) | 83 | 0.0 | — | — |
| b-PLGF 49 (25) | 25 | 26.4 (79) | 82 | 22.8 | 91 | 72 |
| b-PLGF 49 (30) | 30 | 22.8 (64) | 69 | 24.6 | 82 | 52 |
| b-PLGF 49 (35) | 35 | 11.0 (29) | 32 | 26.2 | 75 | 21 |
| b-PLGF 49 (40) | 40 | 4.6 (11) | 14 | 22.4 | 56 | 6.2 |
|
| ||||||
| b-PLGF 73 (0) | 0 | 22.3 (89) | 89 | 0.0 | — | — |
| b-PLGF 73 (25) | 25 | 23.4 (70) | 71 | 23.6 | 95 | 66 |
| b-PLGF 73 (30) | 30 | 18.6 (52) | 56 | 24.1 | 80 | 42 |
| b-PLGF 73 (35) | 35 | 13.4 (35) | 40 | 25.4 | 72 | 25 |
| b-PLGF 73 (40) | 40 | 6.4 (15) | 18 | 28.4 | 71 | 11 |
PR (%) = (polymer found)/( polymer in feed) (w/w) × 100.
DL (%) = (drug found)/(micelle found) (w/w) × 100.
EE (%) = [(drug found)/(micelle found)]/[(drug in feed)/(micelle in feed)] (w/w) × 100.
DR (%) = (drug found)/(drug in feed) (w/w) × 100.