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. 2013 Dec 9;42(5):2803–2819. doi: 10.1093/nar/gkt1277

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Cell migration is a critical process in the tumor invasion-metastasis cascade. Phosphatidylinositol 3-kinase (PI3K) is an important component of the cell migration apparatus. When integrin is activated through fibronectin binding, integrin-linked kinase (ILK) can activate Caspase-8. Caspase-8 interacts with the p85 regulatory subunit of PI3K, and p85 further binds to the catalytic subunit p110 (PIK3CB) of PI3K, thereby promoting cell migration.