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Intereference between structured- and unstructured-RNA transcripts on cellular IFN-β response. A549 fibroblasts were transfected with 9 ng of BV or HPgV RNA at time zero (line 1, x-axis), followed by repeat transfection at 2 h of 9 ng RNA (line 2). IFN-β induction (y-axis) was quantified relative to a poly-I:C control. Bar heights represent the mean of three biological replicates; error bars show SDs.
