Table 1.

Selection criteria and experimental results of promoters of meAP-1-regulated genes in naïve human B cells and the cell line K562

Gene name	Fold upregulationa	CpG methylationb (%)	Distance meAP-1 to TSS (nt)	Distance AP-1 to TSS (nt)	ChIP in primary B cellsc	BS-seqd (%)	ChIP in K562 cellse
DCTPP1	14.03	>98	−678	n.a.	2.5	>98	3.0
SLAMF1	6.13	100	−1698	n.a.	2.6	>90	4.8
UQCRB	3.89	>90	−1244	n.a.	3.0	>98	4.0
SCRIB	3.04	>80	−1625	n.a.	3.3	>90	3.6
VAT1	2.01	>90	−1735	n.a.	2.7	>98	4.2
SAE1	5.79	>90	−718	−2831	2.3	>98	5.3
PSMC1f	4.69	>80	−1418	−2532	3.0	100	6.0
		>90	−929		2.6	n.d.	4.1
ITFG2	3.09	>90	−1007	−4336	2.7	>90	4.4
LARP4B	2.85	>80	−1272	−4707	2.6	>98%	3.6
FGR	2.06	>90	−744	−2004	2.5	>90%	7.0

n.a., not applicable; n.d., not done.

^aTranscriptional activation in naïve B cells 16 h post stimulation (29).

^bmethylome data from resting naïve B cells (28).

^cdata derived from Figure 5, fold enrichment compared with the mean of negative controls.

^dBS-seq; bisulfite sequencing; data derived from Supplementary Figure S8.

^eData derived from Supplementary Figure S7, fold enrichment compared with the mean of negative controls.

^fPSMC1 promoter encompasses two meAP1 and one AP-1 site.