Figure 2.

Simple loop models of topological domains do not recapitulate the 3C data. (A) Contact maps obtained for a simple loop model of two topological domains with sizes corresponding to 800 and 400 kb, respectively. (B) Contact probability profiles obtained in simulations of topological domains as non-supercoiled loops (indicated with continuous lines) and 3C data for individual topological domains E, F and H presented in Figure 1 of Nora et al. (3). Notice that in contrast to the model presented in Figure 1, the simple loop models fail to reproduce the experimental data.