Figure 3.

Overview of the selected reference bins for all target bins on chromosome 21. Cytobands are shown on the outside of the circle along with base pair positions in Mb and chromosome number. Lines connect target bins on chromosome 21 and their corresponding reference bins on other chromosomes. Opacity indicates the amount of overlapping lines. Barely any connections to chromosome 19 are made as the read frequency behavior of bins on chromosome 19 differs too much from the bins on chromosome 21 over different samples. Repeat rich regions such as the acrocentric p-arm of chromosome 21 and the regions surrounding the centromeres could not be mapped, and will therefore not be selected as reference bins. Image made using Circos (21).