Appendix 1.
Medline search strategy for RCT records
| Search | Query | Items found |
|---|---|---|
| #9 | Search (#6 AND #7) AND (“1980/01/01”[Date - Publication] : “2012/06/27”[Date - Publication]) | 914 |
| #8 | Search #6 AND #7 | 914 |
| #7 | Search infant[mh] OR infant*[tiab] OR toddler*[tiab] OR child[mh] OR child*[tiab] OR preschool*[tiab] OR preschool*[tiab] OR schoolchild*[tiab] OR paediatric*[tiab] OR pediatric*[tiab] | 2158897 |
| #6 | Search #3 AND #4 AND #5 | 6912 |
| #5 | Search optimal time[tiab] OR optimal timing[tiab] OR optimum time[tiab] OR optimum timing[tiab] OR time factors[mh] OR time factor[tiab] OR time factors[tiab] OR initiate[tiab] OR initiating[tiab] OR initiation[tiab] OR “when to start”[tiab] OR early treatment[tiab] OR deferred treatment[tiab] OR earlier treatment[tiab] OR best time[tiab] OR best timing[tiab] OR (start*[tiab] AND therapy[tiab]) | 1155983 |
| #4 | Search (randomized controlled trial [pt] OR controlled clinical trial [pt] OR randomized [tiab] OR placebo [tiab] OR drug therapy [sh] OR randomly [tiab] OR trial [tiab] OR groups [tiab]) NOT (animals [mh] NOT humans [mh]) | 2566592 |
| #3 | Search #1 AND #2 | 76113 |
| #2 | Search antiretroviral therapy, highly active[MeSH] OR antiretroviral agents[MeSH] OR antiviral agents[MeSH:NoExp] OR ((anti[tiab]) AND (hiv[tiab])) OR antiretroviral*[tiab] OR ((anti[tiab]) AND (retroviral*[tiab])) OR HAART[tiab] OR ((anti[tiab]) AND (acquired immunodeficiency[tiab])) OR ((anti[tiab]) AND (acquired immunodeficiency[tiab])) OR ((anti[tiab]) AND (acquired immune-deficiency[tiab])) OR ((anti[tiab]) AND (acquired immun*[tiab]) AND (deficiency[tiab])) | 120941 |
| #1 | Search HIV Infections[MeSH] OR HIV[MeSH] OR hiv[tiab] OR hiv-1*[tiab] OR hiv-2*[tiab] OR hiv1[tiab] OR hiv2[tiab] OR hiv infect*[tiab] OR human immunodeficiency virus[tiab] OR human immunedeficiency virus[tiab] OR human immunodeficiency virus[tiab] OR human immunedeficiency virus[tiab] OR ((human immun*[tiab]) AND (deficiency virus[tiab])) OR acquired immunodeficiency syndrome[tiab] OR acquired immunedeficiency syndrome[tiab] OR acquired immunodeficiency syndrome[tiab] OR acquired immunedeficiency syndrome[tiab] OR ((acquired immun*[tiab]) AND (deficiency syndrome[tiab])) OR “sexually transmitted diseases, Viral”[MeSH:NoExp] | 283522 |