eTable. Randomized controlled studies of therapy with antihypertensive drugs, in which neither adherence nor clinical end points were affected in favor of the intervention under study.

Study	Type of intervention / case numbers (control vs intervention)	Effects on adherence and clinical end points
(26)	Calendar blister pack n = 85 vs n = 86	After 3 months: Self assessment of adherence (n.s.) Pill count (n.s.) Systolic blood pressure (n.s.), mean value from the 2 nd and 3 rd measurements of a total of 3
(27)	Verbal and written information on the active ingredient (hydrochlorothiazide) from the pharmacist Monitoring the learning effect resulting from the usual patient education Identifying and solving problems with the medication Checking the success of the intervention n = 30 vs n = 34	After 6 months: Proportion of patients with hydrochlorothiazide confirmed in plasma (n.s.) Self assessment of adherence (n.s.) Ambulatory blood pressure measured electronically: systolic (n.s.) and diastolic (n.s.)
(28)	Intervention group 1: ambulatory blood pressure measurement by patients Intervention group 2: ambulatory blood pressure measurement by study personnel every four weeks Intervention group 3: combination of the two measures described above n = 34 vs n = 34 and n = 33 and n = 35	After 6 months: Self assessment (n.s.) Pill count (n.s.) Reduction in diastolic blood pressure (n.s.)
(29)	Combined preparation instead of two monosubstances n = 104 vs n = 103	After 1, 3, and 6 months: Pill count (n.s.) Blood pressure systolic (n.s.) and diastolic (n.s.), double measurement performed by study personnel, using sphygmomanometer
(30)	30-minute motivation training after 3, 6, 9, and 12 months (topics: identifying and resolving the discrepancy between behavior and objectives) n = 79 vs n = 81 (adherence) and n = 95 vs n = 95 (blood pressure)	After 12 months: Proportion of days with correct intake of medication (by electronic registration of pack opening) (n.s.) Blood pressure systolic (n.s.) and diastolic (n.s.), measurement in the context of normal primary care physician visits by practice nurse or practice assistant, using sphygmomanometer
(32)	Intervention group 1: Care delivered during working hours by an occupational health physician rather than outside working hours by a primary care physician Intervention group 2: Patient education on aspects of hypertension (including sequelae, therapy, importance of adherence) Intervention group 3: Combination of the two measures described above n = 87 (care delivered by occupational health physician), n = 57 (care delivered by primary care physician), n = 80 (patient education), n = 64 (no patient education)	After 6 months: Proportion of patients with good adherence (= intake of a minimum of 80% of medication doses prescribed) (n.s.) Proportion of patients with diastolic blood pressure <90 mmhg (n.s.)
(33)	Discussion with a study nurse of patients’ questions/concerns about te medication at the start of the study (20 minutes) and after 2 months (10 minutes) n = 117 vs n = 128	After 6 months: By electronic recording of: Proportion of days when drugs were taken punctually (every 24±6h or 12±3h) (n.s.) Proportion of days when the correct numbers of pills were taken (n.s.) Ratio of drugs taken to drugs prescribed (n.s.) Blood pressure systolic (n.s.) and diastolic (n.s.)

n.s.: statistically not significant when comparing groups with one another