Table 3. Estimated odds ratio for the association between CSI and each histological type of lung cancer.
|
CSIa |
Ever smokers |
||||
|---|---|---|---|---|---|
| mean±s.d. | Cases (%) | Controls N (%) | ORb | 95% CI | |
|
Squamous cell carcinoma | |||||
| Male | 1.71±0.60 | 786 (98) | 1958 (71) | 6.1 | 5.0–7.3 |
| Female |
1.68±0.48 |
82 (78) |
260 (34) |
13.1 |
6.3–27.3 |
|
P-value for sex × CSI interaction |
P =0.04 |
||||
|
Adenocarcinoma | |||||
| Men (N=759) | 1.61±0.60 | 759 (96) | 1958 (71) | 4.9 | 4.2–5.9 |
| Women (N=221) |
1.43±0.59 |
221 (62) |
260 (34) |
3.6 |
2.5–5.2 |
|
P-value for sex × CSI interaction |
P =0.13 |
||||
|
Small cell carcinoma | |||||
| Male (N=330) | 1.72±0.55 | 330 (99) | 1958 (71) | 6.6 | 5.1–8.5 |
| Female (N=89) |
1.76±0.51 |
89 (94) |
260 (34) |
15.9 |
7.6–33.3 |
| P-value for sex × CSI interaction | P=0.03 | ||||
Abbreviations: CI=confidence interval; CSI=comprehensive smoking index; OR=odds ratio.
a
Mean of CSI calculated among cases ever smokers, according to gender and histology.
b
Odds ratio of lung cancer associated with CSI (considered continuously), adjusted for age at interview (<50, 50–60, ⩾60 years), départements, education and occupational exposure (list A).