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. 2014 Jan 21;110(5):1211–1220. doi: 10.1038/bjc.2013.822

Figure 3.

Figure 3

G-CSF induces proliferation of gastric and colon carcinoma cells. G-CSF treatment induces proliferation by CyQuant assay for DNA content of (A) MKN-45 and AGS gastric carcinoma cells, (B) Caco-2 and DLD1 colon carcinoma cells. Proliferation was further verified by (C) PCNA staining by flow cytometry. (D) Tumour-derived GMF and CMF supernatants induced proliferation of MKN-45 and Caco-2, which was decreased on adding anti-G-CSF neutralising antibodies. The mean±s.e. values are shown as the results of multiple experiments, N=8 *P<0.05 compared with untreated.