Table 1. Demographics, pathology and molecular features of CRC with synchronous colorectal neoplasia.
|
Synchronous colorectal neoplasia |
|||||||
|---|---|---|---|---|---|---|---|
|
Nonea |
Not-advanced adenomab |
Advanced adenomac |
Invasive cancerd |
||||
| n=548, ref. | n=177 | P* | n=106 | P* | n=50 | P* | |
|
Age | |||||||
| Years, mean±s.d. |
63.9±11.8 |
66.8±9.7 |
0.003 |
66.6±10.0 |
0.02 |
64.6±10.8 |
0.70 |
|
Gender | |||||||
| Male | 292 (53.3) | 115 (65.0) | 77 (72.6) | 29 (53.4) | |||
| Female |
256 (46.7) |
62 (35.0) |
0.006 |
29 (27.4) |
<0.001 |
21 (46.6) |
0.52 |
|
Site | |||||||
| Distal | 374 (68.2) | 101 (57.1) | 64 (60.4) | 30 (61.2) | |||
| Proximal |
174 (31.8) |
76 (42.9) |
0.006 |
42 (39.6) |
0.11 |
19 (38.8) |
0.31 |
|
Stage | |||||||
| I–III | 419 (76.5) | 139 (78.5) | 80 (75.5) | 30 (60.0) | |||
| IV |
129 (23.5) |
38 (21.5) |
0.57 |
26 (24.5) |
0.83 |
20 (40.0) |
0.01e |
|
Histotype | |||||||
| Adenoca | 506 (92.3) | 162 (91.5) | 100 (94.3) | 48 (96.0) | |||
| Variant |
42 (7.7) |
15 (8.5) |
0.73 |
6 (5.7) |
0.47 |
2 (4.0) |
0.34 |
|
Gradef | |||||||
| G1–G2 | 406 (79.3) | 143 (83.6) | 78 (77.2) | 38 (77.6) | |||
| G3 |
106 (20.7) |
28 (16.4) |
0.22 |
23 (22.8) |
0.64 |
11 (22.4) |
0.77 |
|
Vein invasion | |||||||
| No | 423 (77.2) | 140 (79.1) | 82 (77.4) | 36 (72.0) | |||
| Yes |
125 (22.8) |
37 (20.9) |
0.60 |
24 (22.6) |
0.97 |
14 (28.0) |
0.40 |
|
MS status | |||||||
| MSS | 495 (90.3) | 153 (86.4) | 100 (94.3) | 39 (78.0) | |||
| MSI-sporadic | 36 (6.6) | 19 (10.7) | 0.04g | 5 (4.7) | 0.44 | 2 (4.0) | 0.64 |
| HNPCC |
17 (3.1) |
5 (2.8) |
0.92 |
1 (0.9) |
0.20 |
9 (18.0) |
<0.001e |
|
BRAF | |||||||
| BRAF WT | 516 (94.2) | 158 (89.3) | 100 (94.3) | 47 (94.0) | |||
| BRAF c.1799T>A | 32 (5.8) | 19 (10.7) | 0.02g | 6 (5.7) | 0.94 | 3 (6.0) | 0.96 |
Abbreviations: CRC=colorectal cancer; MSI=microsatellite instability; MSS=microsatellite-stable.
At Fisher's exact test.
‘No adenoma'.
‘Low-grade dysplasia <10 mm tubular adenoma, no serrated adenoma.
Forty-five patients with low-grade dysplasia adenoma ⩾10 mm or with villous component >25%, 59 with high-grade dysplasia adenoma, 2 with ⩾10 mm low-grade dysplasia serrated adenoma.
Pathological and molecular characteristics of the most advanced cancer (‘index' lesion, by pT) were to be inserted. Of 23 pairs with identical pT (no ‘index' lesion assessable), 22 had fully concordant pathological and molecular features, whereas one pair with discordant tumour site was excluded from the analysis of this variable.
Interactions at multivariate analysis (logistic regression): ‘Stages I–II vs III–IV' * ‘MS status', P=0.03.
Not assessed in 48 cases (34, 6, 7 and 1 in the four subclasses, respectively).
‘BRAF status' * ‘MS status' (excluding HNPCC), P=0.04.